Autism Spectrum Disorder

 

  • Stereotypical repetitive behaviors
  • Impaired social interaction
  • Deficits in communication

About Autism Spectrum Disorder

ASD is a group of Neurodevelopmental disorder characterized by three core behavioral features: stereotypical repetitive behaviors, impaired social interaction and deficits in communication. ASD is also characterized by significant heterogeneity in genetic background, phenotypical and clinical presentation.

A highly common condition

ASD is a highly common condition with an estimated prevalence of 1 in 59 school-aged children in the United States (Centers for Disease Control and Prevention) and 1 in 100 in the EU. Estimates are 10 million patients in Europe and North America.

It is a highly common condition with approximately
10 million patients in Europe and North America

Unmet need in ASD

High economic burden:

ASD has a significant impact on the long-term quality of life of people living with the condition and their families and represents a considerable burden to both healthcare economies and society. There is currently no cure for ASD.

Lack of clear diagnostic:

Diagnosis is based on clinical behavioral observation, which does not give insight into the genetic or molecular basis of the disease. 80% of ASD cases are idiopathic (autism with no currently identifiable genetic cause). There are currently no laboratory diagnostic tests.

One size fits all approach to treatment:

Only two drugs are currently approved for use in patients with ASD. These drugs only treat irritability that can be associated with the condition and not the core symptoms, and they have a number of side effects. In current clinical trials for idiopathic autism, the same drug is given to all patients who behave in a similar way. This ‘one size fits all’ approach has been a major contributor to the failure in trials conducted in the last decade.

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